Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats

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Impact of inulin and oligofructose on gastrointestinal peptides.

In the present paper, we summarise the data supporting the following hypothesis: dietary inulin-type fructans extracted from chicory root may modulate the production of peptides, such as incretins, by endocrine cells present in the intestinal mucosa, this phenomenon being involved in the regulation of food intake and/or systemic effects. To test this hypothesis, male Wistar rats received for 3 ...

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Introducing inulin-type fructans.

Inulin is a generic term to cover all beta(2-->1) linear fructans. Chicory inulin is a linear beta(2-->1) fructan (degree of polymerisation (DP) 2 to 60; DPav=12), its partial enzymatic hydrolysis product is oligofructose (DP 2 to 8; DPav=4), and by applying specific separation technologies a long-chain inulin known as inulin HP (DP 10 to 60; DPav=25) can be produced. Finally, a specific produc...

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Glucagon-like peptide-1, satiety and appetite control.

After eating a meal several subjective and behavioural changes occur. Normally hunger is reduced, the feeling of fullness increases and eating is inhibited. This state is called post-ingestive satiety: the inhibition of appetite resulting from food consumption. What mechanisms control this phenomenon? During and after eating there occurs a series of overlapping physiological responses, most of ...

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EFFECTS OF AEROBIC TRAINING ON DIPEPTIDYL PEPTIDASE-4 AND GLUCAGON-LIKE PEPTIDE-1 IN OBESE WOMEN WITH TYPE 2 DIABETES

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Appetite and gastrointestinal motility: role of ghrelin-family peptides.

Eating disorders, obesity and cachexia endanger the lives of millions of people worldwide. Fortunately, in last decade, there has been a rapid and substantial progress toward uncovering the molecular and neural mechanisms by which energy imbalance develops. In 1999, ghrelin was identified as the first orexigenic gut-derived peptide. It stimulates appetite and controls the gastric motility and t...

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ژورنال

عنوان ژورنال: British Journal of Nutrition

سال: 2004

ISSN: 0007-1145,1475-2662

DOI: 10.1079/bjn20041225